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@steve12 I don't have access to the full study, but I assume/hope that was an obvious factor they considered. They did say GLP-1 agonists showed a significant decrease compared to metformin. And metformin literally reduces mTOR. Hope I don't have to explain how important that is for building...

@orchardllc I'm pretty sure semaglutide and other GLP-1 agonists have been shown to increase the loss of skeletal muscle tissue vs fat. Meta-analysis: https://pubmed.ncbi.nlm.nih.gov/32628589/ "Although semaglutide, dapaglifrozin, and canagliflozin have a large weight loss effect, it is...