@te15 Problems with this view.
Firstly, the Avilés-Gaxiola Sara et al article initially gives a table on the TI content on the raw beans/legumes. Yes it is high for soya. But if you read through it talks in great detail about a process called extrusion which is a process known to reduce anti-nutrient content as well as maintain the nutritional profile. This process has helped even "hard-to-cook" legumes to be consumed as a snack. The process which is an essential step in the manufacturing of soya chunks. So by the process itself, soya chunks have significantly less amount of anti-nutrients by virtue of the process by which it is made. So to bracket soy beans and soya chunks together and making a case for high Trypsin inhibitors by citing an article that actually talks about reviewing the methods for reducing anti-nutrient content was uncalled for.
Secondly, the other studies cited with a one sentence heading lifted from the abstract that is freely available in
PubMed or Scopus or wherever they are indexed is just bad search strategy.
Volek et al article had a high drop out rate which is termed attrition bias when critically reviewing RCTs. The final list of participants who completed the actually test was just 19 to 22 people in each group. The derivation of statistical significance from such a small sample size is in of itself faulty. The gains in lean body mass which they derived here were in the context of body fat and the authors themselves are saying it in the article. Even for the correlation with maximal strength, the authors claim it could also be partly attributed to neural adaptations
Again the Kraemer et al article the authors themselves give a disclaimer as to the majority of evidence from previous research which points to no consensus on the role of isoflavones in reducing testosterone. Then the following articles like Goodin et al and Thorpe et al were done in the context of prostate cancer and to see if soy supplementation can reduce serum testosterone which is a biomarker for prostate cancer. The Goodin et al study themselves mention the Thorpe et al study to have used a significantly high isoflavone content for their study purpose. They also cite several studies which did not find any correlation between serum testosterone and soy isoflavones.
And citing very ancient literature just because they were an RCT which would have been subsequently proved/disproved through later systematic reviews is to, quote Deadpool, just lazy writing. Seriously a 1991 Ishizuki article on the goitrogenic effect of soy???
Which brings me to, finally Free Androgen Index is an obsolete measurement which has now been disowned by the Endocrine Society.
I am not advocating for soya or against it. Nor am I against whey or any animal protein source. I just want to let everyone know that backing your view with terrible research to forward your own, for lack of a better word, agenda, is bad.
So please do better research.
And for the audience always go with your doctor's advice. They know better.
PS: I am a pathology resident and review journal articles periodically.