Study: https://www.tandfonline.com/doi/full/10.1080/02640414.2024.2321021
Summary:
Key Points:
Pros: This study design is very solid at trying to reduce confounding factors as much as possible.
Within person design: 1 leg trained to failure the other leg to 1-2 RIR
The participants did as many sets as their usual program
They used trained lifters.
Someone oversaw the training to ensure they don't slack off with the intensity
Findings: Overall similar gains
Regional Hypertrophy: the vastus lateralis slightly favored failure training
The rectus femoris favored non failure training
The Leg press was trained first with the leg extension afterwards, so this could indicate some important considerations regarding failure training and exercise order since we know that the rec fem grows better in the leg extension.
Fatigue: Higher in the RIR 0 groups but sadly only measured on training days, 24 and 48h post would have been interesting.
Summary:
Increases in quadriceps thickness (average of RF [Rectus femoris] and VL [vastus lateralis]) from pre- to post-intervention were similar for FAIL [0.181 cm (HDI: 0.119 to 0.243)] and RIR [0.182 cm (HDI: 0.115 to 0.247)]. Between-protocol differences in RF thickness slightly favoured RIR [−0.036 cm (HDI: −0.113 to 0.047)], but VL thickness slightly favoured FAIL [0.033 cm (HDI: −0.046 to 0.116)].
Lifting velocity and repetition loss were consistently greater for FAIL versus RIR, with the magnitude of difference influenced by the exercise and the stage of the RT intervention.
Key Points:
Terminating RT sets with a close proximity-to-failure (e.g., 1- to 2-RIR) can be sufficient to promote similar hypertrophy of the quadriceps as reaching momentary muscular failure in resistance-trained individuals over eight weeks, but the overall influence of proximity-to-failure on muscle-specific hypertrophy may also depend on other factors (e.g., exercise selection, order, and subsequent musculature targeted).
Due to high repetition loss (from the first to final set) when sets are terminated at momentary muscular failure, performing RT with 1- to 2-RIR allows for similar volume load and repetition volume accumulation as reaching momentary muscular failure across eight weeks, possibly influencing the overall RT stimulus achieved.
Performing RT to momentary muscular failure consistently induces higher levels of acute neuromuscular fatigue versus RT performed with 1- to 2-RIR; however, improved fatigue resistance overtime may attenuate acute neuromuscular fatigue and subsequent repetition loss (but may depend on the exercise performed).
Pros: This study design is very solid at trying to reduce confounding factors as much as possible.
Within person design: 1 leg trained to failure the other leg to 1-2 RIR
The participants did as many sets as their usual program
They used trained lifters.
Someone oversaw the training to ensure they don't slack off with the intensity
Findings: Overall similar gains
Regional Hypertrophy: the vastus lateralis slightly favored failure training
The rectus femoris favored non failure training
The Leg press was trained first with the leg extension afterwards, so this could indicate some important considerations regarding failure training and exercise order since we know that the rec fem grows better in the leg extension.
Fatigue: Higher in the RIR 0 groups but sadly only measured on training days, 24 and 48h post would have been interesting.