@acushla I have no idea about which studies you're talking. To my knowledge and recent check on new evidence, anything above or at 30%rm is equally effective for hypertrophy. Besides that there seem to be people reacting differently well to high, medium or low load within this range. However nothing of this has any to do with the risk/reward issue and fatigue problem. It's known that hypertrophy is a reaction to mechanical tension on the muscle fibers at low contraction velocity, so that's the primary factor you need, but besides that there're other factors interacting with just this one. For owe it to yourself/clients /athletes to look at resistance training in a holistic way.
PS: If you could provide a link to the specific research you're referring to I'd be thankful AND will take an sincerely look at it.
PS: If you could provide a link to the specific research you're referring to I'd be thankful AND will take an sincerely look at it.